AlphaFold predicted structure
FOXM1 · Q08050
Mean pLDDT
50.2/ 100
Low
763 residues
Confidence breakdown
- Very high(≥ 90)11%
- Confident(70–90)7%
- Low(50–70)10%
- Very low(< 50)72%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
FOXM1
Chr 12p13.33forkhead box M1
- Aliases:
- HFH-11, trident, HNF-3, INS-1, MPP2
- MANE:
- ENST00000359843.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Cerebral vascular malformations
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownCOVID-19 research
UnknownPrimary immunodeficiency or monogenic inflammatory bowel disease
Unknown
Disease associations (Open Targets)
cancer
0.49Alzheimer disease
0.29Parkinson disease
0.28multiple sclerosis
0.27neurodegenerative disease
0.27lysosomal storage disease
0.27Moyamoya disease
0.20hepatocellular carcinoma
0.13central nervous system cancer
0.13breast carcinoma
0.12
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Forkhead box protein M1
Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036)
Diseases associated with FOXM1
Curated MONDO disease pages that list FOXM1 among their top associated genes.