FOXP4

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• DDG2P

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Fetal anomalies

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Paediatric disorders - additional genes

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Intellectual disability

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Monogenic short stature

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

• neurodevelopmental disorder

  0.59

• neurodegenerative disease

  0.52

• prostate carcinoma

  0.47

• ventricular septal defect

  0.41

• prostate cancer

  0.38

• congenital diaphragmatic hernia

  0.37

• Short stature

  0.34

• Flattened epiphysis

  0.34

• Disproportionate short stature

  0.34

• Craniofacial asymmetry

  0.34

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with FOXP4

Curated MONDO disease pages that list FOXP4 among their top associated genes.

• neurodevelopmental disorderRare