FRYL

Chr 4p11

FRY like transcription coactivator

Aliases:: DKFZp686E205, AF4p12, MOR2
MANE:: ENST00000358350.9

OMIM: 620798 ↗NCBI: 285527 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FRYL · O94915-2isoform

No predicted structure exists for the canonical O94915 sequence; metrics below describe this isoform.

v62025-08-01

Predicted Aligned Error matrix for FRYL — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.4/ 100

Confident

403 residues

Confidence breakdown

Very high(≥ 90)47%
Confident(70–90)26%
Low(50–70)13%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Pan-Chung-Bellen syndrome
0.66
type 2 diabetes mellitus
0.26
migraine disorder
0.26
dementia
0.24
thrombophilia
0.20
menopause
0.13
nephronophthisis
0.08
Abnormality of the skeletal system
0.08
posterior cortical atrophy
0.08
familial idiopathic steroid-resistant nephrotic syndrome
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein furry homolog-like

Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator