AlphaFold predicted structure
FSHB · P01225
Mean pLDDT
89.8/ 100
Confident
129 residues
Confidence breakdown
- Very high(≥ 90)78%
- Confident(70–90)6%
- Low(50–70)13%
- Very low(< 50)2%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
FSHB
Chr 11p14.1follicle stimulating hormone subunit beta
- MANE:
- ENST00000533718.2
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Hypogonadotropic hypogonadism
BIALLELIC, autosomal or pseudoautosomalHypogonadotropic hypogonadism (GMS)
BIALLELIC, autosomal or pseudoautosomalPrimary ovarian insufficiency
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
Isolated follicle stimulating hormone deficiency
0.74hypogonadotropic hypogonadism 24 without anosmia
0.71endometriosis
0.51polycystic ovary syndrome
0.48uterine corpus leiomyoma
0.48Menorrhagia
0.46Menstrual disorder
0.43Ovarian cyst
0.41positive regulation of ovulation
0.39female reproductive system disorder
0.38
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Follitropin subunit beta
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:24692546, PubMed:2494176). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432)
Diseases associated with FSHB
Curated MONDO disease pages that list FSHB among their top associated genes.