FSHR

Chr 2p16.3

follicle stimulating hormone receptor

Aliases:: FSHRO, LGR1
MANE:: ENST00000406846.7

OMIM: 136435 ↗NCBI: 2492 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

FSHR · P23945

v62025-08-01

Predicted Aligned Error matrix for FSHR — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.8/ 100

Confident

695 residues

Confidence breakdown

Very high(≥ 90)54%
Confident(70–90)25%
Low(50–70)9%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary ovarian insufficiency
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

46,XX gonadal dysgenesis
0.77
ovarian hyperstimulation syndrome
0.75
Infertility
0.59
hypogonadotropic hypogonadism
0.56
anovulation
0.55
primary ovarian failure
0.55
female infertility
0.55
infertility disorder
0.53
hypogonadism
0.50
genetic non-acquired premature ovarian failure
0.50

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Follicle-stimulating hormone receptor

G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690)

Curated MONDO disease pages that list FSHR among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with FSHR