AlphaFold predicted structure
FUT2 · Q10981
Mean pLDDT
90.3/ 100
Very high
343 residues
Confidence breakdown
- Very high(≥ 90)81%
- Confident(70–90)9%
- Low(50–70)2%
- Very low(< 50)8%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
FUT2
Chr 19q13.33fucosyltransferase 2 (H blood group)
- Aliases:
- sej, Se2, SEC2
- MANE:
- ENST00000425340.3
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalEarly onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalRare anaemia
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
cholelithiasis
0.53hypertensive disorder
0.52COVID-19
0.52peptic ulcer disease
0.51Hypercholesterolemia
0.51vitamin B deficiency
0.49vitamin B12 deficiency
0.48essential hypertension
0.48type 1 diabetes mellitus
0.48substance-related disorder
0.47
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Galactoside alpha-(1,2)-fucosyltransferase 2
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:12692541, PubMed:7876235, PubMed:8018146). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:22068912, PubMed:24733310). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235)
Diseases associated with FUT2
Curated MONDO disease pages that list FUT2 among their top associated genes.