AlphaFold predicted structure
FXYD2 · P54710
Mean pLDDT
75.6/ 100
Confident
66 residues
Confidence breakdown
- Very high(≥ 90)38%
- Confident(70–90)14%
- Low(50–70)46%
- Very low(< 50)3%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
FXYD2
Chr 11q23.3FXYD domain containing ion transport regulator 2
- Aliases:
- MGC12372
- MANE:
- ENST00000292079.7
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Renal tubulopathies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedLikely inborn error of metabolism
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownUndiagnosed metabolic disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
congestive heart failure
0.60atrial fibrillation
0.60heart failure
0.58renal hypomagnesemia 2
0.55cardiovascular disorder
0.55Autosomal dominant primary hypomagnesemia with hypocalciuria
0.52Arrhythmia
0.50type 2 diabetes mellitus
0.47neurodegenerative disease
0.41Supraventricular tachycardia
0.32
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Sodium/potassium-transporting ATPase subunit gamma
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase