FYB1

Chr 5p13.1

FYN binding protein 1

Aliases:: SLAP-130, FYB-120/130, ADAP
MANE:: ENST00000512982.4

OMIM: 602731 ↗NCBI: 2533 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FYB1 · O15117

v62025-08-01

Predicted Aligned Error matrix for FYB1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

56.6/ 100

Low

783 residues

Confidence breakdown

Very high(≥ 90)13%
Confident(70–90)15%
Low(50–70)15%
Very low(< 50)57%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
BIALLELIC, autosomal or pseudoautosomal
Cytopenia - NOT Fanconi anaemia
BIALLELIC, autosomal or pseudoautosomal
Inherited bleeding disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

thrombocytopenia 3
0.68
hereditary thrombocytopenia with normal platelets
0.56
blood platelet disease
0.37
ulcerative colitis
0.27
macular degeneration
0.27
degeneration of macula and posterior pole
0.27
age-related macular degeneration
0.27
retinal disorder
0.26
neuroendocrine neoplasm
0.26
sinusitis
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

FYN-binding protein 1

Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity)