FYCO1

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Bilateral congenital or childhood onset cataracts

  BIALLELIC, autosomal or pseudoautosomal

• DDG2P

  BIALLELIC, autosomal or pseudoautosomal

• Fetal anomalies

  BIALLELIC, autosomal or pseudoautosomal

• Intellectual disability

  BIALLELIC, autosomal or pseudoautosomal

• Structural eye disease

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• Partial congenital cataract

  0.75

• early-onset non-syndromic cataract

  0.64

• early-onset nuclear cataract

  0.63

• early-onset zonular cataract

  0.52

• COVID-19

  0.48

• Developmental cataract

  0.46

• hereditary disease

  0.42

• Total congenital cataract

  0.39

• cataract

  0.39

• total early-onset cataract

  0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with FYCO1

Curated MONDO disease pages that list FYCO1 among their top associated genes.

• early-onset non-syndromic cataractRare
• early-onset zonular cataractRare