GAS2L2

Chr 17q12

growth arrest specific 2 like 2

Aliases:: GAR17
MANE:: ENST00000604641.6

OMIM: 611398 ↗NCBI: 246176 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

GAS2L2 · Q8NHY3

v62025-08-01

Predicted Aligned Error matrix for GAS2L2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

55.7/ 100

Low

880 residues

Confidence breakdown

Very high(≥ 90)20%
Confident(70–90)10%
Low(50–70)10%
Very low(< 50)61%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Primary ciliary disorders
BIALLELIC, autosomal or pseudoautosomal
Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

primary ciliary dyskinesia
0.60
upper respiratory tract disorder
0.27
non-suppurative otitis media
0.27
middle ear disorder
0.27
Abnormal mastoid morphology
0.27
chronic rhinosinusitis
0.27
sinusitis
0.27
Congenital pulmonary alveolar proteinosis
0.06
Neonatal acute respiratory distress with surfactant metabolism deficiency
0.06
Heterotaxia
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

GAS2-like protein 2

Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G protein complexes to ADORA2A (By similarity). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704)