GATAD1

Chr 7q21.2

GATA zinc finger domain containing 1

Aliases:: ODAG, RG083M05.2, FLJ22489
MANE:: ENST00000287957.5

OMIM: 614518 ↗NCBI: 57798 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

GATAD1 · Q8WUU5

v62025-08-01

Predicted Aligned Error matrix for GATAD1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

70.6/ 100

Confident

269 residues

Confidence breakdown

Very high(≥ 90)32%
Confident(70–90)20%
Low(50–70)21%
Very low(< 50)27%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Dilated Cardiomyopathy and conduction defects
BIALLELIC, autosomal or pseudoautosomal
Dilated and arrhythmogenic cardiomyopathy
Hereditary neuropathy
Hereditary neuropathy or pain disorder

Disease associations (Open Targets)

neurodegenerative disease
0.49
dilated cardiomyopathy
0.46
dilated cardiomyopathy 2B
0.46
familial isolated dilated cardiomyopathy
0.42
Zellweger spectrum disorders
0.34
Zellweger syndrome
0.34
Abnormality of the cardiovascular system
0.19
neoplasm
0.08
glioblastoma
0.08
hepatocellular carcinoma
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

GATA zinc finger domain-containing protein 1

Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3)