GC

Chr 4q13.3

GC vitamin D binding protein

Aliases:: DBP, VDBP, hDBP
MANE:: ENST00000273951.13

OMIM: 139200 ↗NCBI: 2638 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

GC · P02774

v62025-08-01

Predicted Aligned Error matrix for GC — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

92.7/ 100

Very high

474 residues

Confidence breakdown

Very high(≥ 90)89%
Confident(70–90)7%
Low(50–70)0%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

vitamin D deficiency
0.56
vitamin deficiency disorder
0.53
chronic obstructive pulmonary disease
0.50
central nervous system cancer
0.33
squamous cell carcinoma
0.32
placental retention
0.30
coronary artery calcification
0.26
cervical carcinoma
0.26
placental abruption
0.24
COVID-19
0.23

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Vitamin D-binding protein

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation

Curated MONDO disease pages that list GC among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with GC