GCC2

Chr 2q12.3

GRIP and coiled-coil domain containing 2

Aliases:: GCC185, KIAA0336
MANE:: ENST00000309863.11

OMIM: 612711 ↗NCBI: 9648 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

GCC2 · Q8IWJ2

v62025-08-01

Predicted Aligned Error matrix for GCC2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

71.7/ 100

Confident

1,684 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)74%
Low(50–70)13%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

cancer
0.48
kidney disorder
0.27
immune system disorder
0.18
Immunodeficiency
0.18
immunodeficiency disease
0.18
Progressive sensorineural hearing impairment
0.11
Hirsutism
0.09
non-small cell lung carcinoma
0.09
lung cancer
0.08
lung carcinoma
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

GRIP and coiled-coil domain-containing protein 2

Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2