AlphaFold predicted structure
GDI1 · P31150
Mean pLDDT
93.4/ 100
Very high
447 residues
Confidence breakdown
- Very high(≥ 90)88%
- Confident(70–90)8%
- Low(50–70)3%
- Very low(< 50)1%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
GDI1
Chr Xq28GDP dissociation inhibitor 1
- Aliases:
- RABGDIA, XAP-4, OPHN2, FLJ41411
- MANE:
- ENST00000447750.7
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Intellectual disability
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesDDG2P
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesFetal anomalies
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Disease associations (Open Targets)
X-linked non-syndromic intellectual disability
0.73non-syndromic X-linked intellectual disability
0.46hereditary disease
0.45Intellectual disability
0.37X-linked intellectual disability, Siderius type
0.37Alzheimer disease
0.35multiple sclerosis
0.34Parkinson disease
0.34neurodegenerative disease
0.34lysosomal storage disease
0.34
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Rab GDP dissociation inhibitor alpha
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes