AlphaFold predicted structure
GFM2 · Q969S9
Mean pLDDT
78.6/ 100
Confident
779 residues
Confidence breakdown
- Very high(≥ 90)24%
- Confident(70–90)58%
- Low(50–70)8%
- Very low(< 50)10%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
GFM2
Chr 5q13.3GTP dependent ribosome recycling factor mitochondrial 2
- Aliases:
- EFG2, FLJ21661, EF-G2mt
- MANE:
- ENST00000296805.8
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorders
BIALLELIC, autosomal or pseudoautosomalPossible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalArthrogryposis
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
combined oxidative phosphorylation deficiency
0.73mitochondrial disease
0.46Leigh syndrome
0.22hereditary disease
0.19Alzheimer disease
0.19neurodegenerative disease
0.19Parkinson disease
0.19multiple sclerosis
0.19lysosomal storage disease
0.19Sandhoff disease
0.17
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Ribosome-releasing factor 2, mitochondrial
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with MRRF (PubMed:19716793, PubMed:33878294). Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts (PubMed:33878294). GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit (PubMed:19716793). Not involved in the GTP-dependent ribosomal translocation step during translation elongation (PubMed:19716793)