GIGYF2

Chr 2q37.1

GRB10 interacting GYF protein 2

Aliases:: KIAA0642, GYF2
MANE:: ENST00000373563.9

OMIM: 612003 ↗NCBI: 26058 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

GIGYF2 · Q6Y7W6

v62025-08-01

Predicted Aligned Error matrix for GIGYF2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

56.4/ 100

Low

1,299 residues

Confidence breakdown

Very high(≥ 90)5%
Confident(70–90)30%
Low(50–70)13%
Very low(< 50)52%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Adult onset neurodegenerative disorder
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Adult onset dystonia, chorea or related movement disorder
Intellectual disability
Parkinson Disease and Complex Parkinsonism

Disease associations (Open Targets)

neurodegenerative disease
0.53
Leber congenital amaurosis 16
0.52
schizophrenia
0.40
Parkinson disease
0.39
snowflake vitreoretinal degeneration
0.37
mathematical ability
0.37
Leber congenital amaurosis
0.33
Hereditary late-onset Parkinson disease
0.33
esophageal disorder
0.31
coronary artery disorder
0.31

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

GRB10-interacting GYF protein 2

Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578)