GIMAP5

Chr 7q36.1

GTPase, IMAP family member 5

Aliases:: HIMAP3, IAN5
MANE:: ENST00000358647.5

OMIM: 608086 ↗NCBI: 55340 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

GIMAP5 · Q96F15

v62025-08-01

Predicted Aligned Error matrix for GIMAP5 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

89.4/ 100

Confident

307 residues

Confidence breakdown

Very high(≥ 90)78%
Confident(70–90)14%
Low(50–70)1%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

portal hypertension, noncirrhotic, 2
0.54
portal hypertension
0.37
lymphopenia
0.19
Autoimmunity
0.19
liver disorder
0.19
immunodeficiency disease
0.19
immune system disorder
0.19
Immunodeficiency
0.19
retinitis pigmentosa
0.10
posterior polymorphous corneal dystrophy
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

GTPase IMAP family member 5

Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity)