AlphaFold predicted structure
GNA14 · O95837
Mean pLDDT
93.5/ 100
Very high
355 residues
Confidence breakdown
- Very high(≥ 90)85%
- Confident(70–90)12%
- Low(50–70)2%
- Very low(< 50)1%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
GNA14
Chr 9q21.2G protein subunit alpha 14
- MANE:
- ENST00000341700.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownMosaic skin disorders - deep sequencing
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
tufted angioma
0.41vascular neoplasm
0.37Choreoacanthocytosis
0.34chorea-acanthocytosis
0.34subarachnoid hemorrhage
0.32stroke disorder
0.30alcohol drinking
0.30central nervous system cancer
0.29cornea transplantation
0.29tooth disorder
0.29
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Guanine nucleotide-binding protein subunit alpha-14
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems
Diseases associated with GNA14
Curated MONDO disease pages that list GNA14 among their top associated genes.