GNB4

Chr 3q26.33

G protein subunit beta 4

MANE:: ENST00000232564.8

OMIM: 610863 ↗NCBI: 59345 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

GNB4 · Q9HAV0

v62025-08-01

Predicted Aligned Error matrix for GNB4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

97.1/ 100

Very high

340 residues

Confidence breakdown

Very high(≥ 90)97%
Confident(70–90)3%
Low(50–70)0%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Hereditary neuropathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Hereditary neuropathy or pain disorder
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Charcot-Marie-Tooth disease dominant intermediate F
0.64
Autosomal dominant intermediate Charcot-Marie-Tooth disease type F
0.64
atrial fibrillation
0.49
breast disorder
0.28
kidney disorder
0.28
Charcot-Marie-Tooth disease
0.22
hereditary disease
0.19
breast carcinoma
0.12
gastric cancer
0.10
Uterine leiomyoma
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Guanine nucleotide-binding protein subunit beta-4

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction