AlphaFold predicted structure
GNRH1 · P01148
Mean pLDDT
72.2/ 100
Confident
92 residues
Confidence breakdown
- Very high(≥ 90)12%
- Confident(70–90)42%
- Low(50–70)42%
- Very low(< 50)3%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
GNRH1
Chr 8p21.2gonadotropin releasing hormone 1
- Aliases:
- LNRH
- MANE:
- ENST00000421054.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Hypogonadotropic hypogonadism
BIALLELIC, autosomal or pseudoautosomalHypogonadotropic hypogonadism (GMS)
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
hypogonadotropic hypogonadism 12 with or without anosmia
0.55isolated congenital hypogonadotropic hypogonadism
0.51hypogonadotropic hypogonadism
0.48isolated thyroid-stimulating hormone deficiency
0.37endometriosis
0.31uterine corpus leiomyoma
0.25alcohol drinking
0.14type 2 diabetes mellitus
0.13chondromalacia
0.12amenorrhea
0.12
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Progonadoliberin-1
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones
Diseases associated with GNRH1
Curated MONDO disease pages that list GNRH1 among their top associated genes.