GON4L

Chr 1q22

gon-4 like

Aliases:: FLJ20203, GON-4, YARP
MANE:: ENST00000368331.6

OMIM: 610393 ↗NCBI: 54856 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

GON4L · Q3T8J9

v62025-08-01

Predicted Aligned Error matrix for GON4L — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

47.7/ 100

Very low

2,241 residues

Confidence breakdown

Very high(≥ 90)9%
Confident(70–90)14%
Low(50–70)9%
Very low(< 50)67%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Li-Takada-Miyake syndrome
0.52
neurodegenerative disease
0.52
atrial fibrillation
0.26
Abnormality of the skeletal system
0.25
nervous system disorder
0.23
gastric carcinoma
0.20
ependymoma
0.11
hemorrhage
0.10
gastric ulcer
0.10
gout
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

GON-4-like protein

Acts as a key transcription regulator of histones (PubMed:25339177, PubMed:40516528, PubMed:40516529). Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with GON4L and MIZF (PubMed:25339177). Together with CRAMP1, binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x), driving their transcription (PubMed:40516528, PubMed:40516529). Also acts as a transcription corepressor, as part of a complex with YY1, SIN3A and HDAC1 (By similarity). Required for B-cell lymphopoiesis (By similarity)