GP6

Chr 19q13.42

glycoprotein VI platelet

Aliases:: GPVI
MANE:: ENST00000417454.5

OMIM: 605546 ↗NCBI: 51206 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

GP6 · Q9HCN6

v62025-08-01

Predicted Aligned Error matrix for GP6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.1/ 100

Confident

339 residues

Confidence breakdown

Very high(≥ 90)55%
Confident(70–90)7%
Low(50–70)14%
Very low(< 50)25%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
BIALLELIC, autosomal or pseudoautosomal
Inherited bleeding disorders
BIALLELIC, autosomal or pseudoautosomal
Autoinflammatory disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

platelet-type bleeding disorder 11
0.72
Bleeding diathesis due to glycoprotein VI deficiency
0.64
venous thromboembolism
0.49
Thromboembolism
0.44
platelet aggregation
0.43
deep vein thrombosis
0.37
stroke disorder
0.25
hereditary disease
0.19
brain infarction
0.19
Abnormal bleeding
0.15

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Platelet glycoprotein VI

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2