GP9

Chr 3q21.3

glycoprotein IX platelet

Aliases:: CD42a, GPIX
MANE:: ENST00000307395.5

OMIM: 173515 ↗NCBI: 2815 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

GP9 · P14770

v62025-08-01

Predicted Aligned Error matrix for GP9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.7/ 100

Confident

177 residues

Confidence breakdown

Very high(≥ 90)61%
Confident(70–90)20%
Low(50–70)18%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
BIALLELIC, autosomal or pseudoautosomal
Inherited bleeding disorders
BIALLELIC, autosomal or pseudoautosomal
Cytopenia - NOT Fanconi anaemia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Bernard-Soulier syndrome
0.82
Macrothrombocytopenia
0.46
Brooke-Spiegler syndrome
0.37
Barber-Say syndrome
0.37
Thrombocytopenia
0.31
hereditary disease
0.19
gastrointestinal disease
0.12
autosomal dominant macrothrombocytopenia
0.07
acute megakaryoblastic leukemia
0.06
hereditary thrombocytopenia with normal platelets
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Platelet glycoprotein IX

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib