GPATCH3

Chr 1p36.11

G-patch domain containing 3

Aliases:: FLJ12455
MANE:: ENST00000361720.10

OMIM: 617486 ↗NCBI: 63906 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

GPATCH3 · Q96I76

v62025-08-01

Predicted Aligned Error matrix for GPATCH3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

67.1/ 100

Low

525 residues

Confidence breakdown

Very high(≥ 90)4%
Confident(70–90)50%
Low(50–70)26%
Very low(< 50)20%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

neurodegenerative disease
0.27
coronary atherosclerosis
0.10
gout
0.09
Familial exudative vitreoretinopathy
0.06
Isolated anophthalmia - microphthalmia
0.06
microphthalmia
0.06
nanophthalmia
0.05
congenital primary aphakia
0.05
persistent hyperplastic primary vitreous
0.05
retinitis pigmentosa
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

G patch domain-containing protein 3

Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860). Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768)