GPC4

Chr Xq26.2

glypican 4

Aliases:: K-glypican
MANE:: ENST00000370828.4

OMIM: 300168 ↗NCBI: 2239 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

GPC4 · O75487

v62025-08-01

Predicted Aligned Error matrix for GPC4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.2/ 100

Confident

556 residues

Confidence breakdown

Very high(≥ 90)69%
Confident(70–90)9%
Low(50–70)7%
Very low(< 50)15%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Intellectual disability
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Fetal anomalies
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Rare syndromic craniosynostosis or isolated multisuture synostosis
X-LINKED: hemizygous mutation in males, biallelic mutations in females

Disease associations (Open Targets)

Keipert syndrome
0.74
COVID-19
0.54
dengue disease
0.46
neurodegenerative disease
0.37
Distal shortening of limbs
0.27
craniosynostosis
0.26
hereditary disease
0.19
Alzheimer disease
0.10
polycystic ovary syndrome
0.09
Blackfan-Diamond anemia
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Glypican-4

Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity)