GPC6

Chr 13q31.3-q32.1

glypican 6

MANE:: ENST00000377047.9

OMIM: 604404 ↗NCBI: 10082 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

GPC6 · Q9Y625

v62025-08-01

Predicted Aligned Error matrix for GPC6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.0/ 100

Confident

555 residues

Confidence breakdown

Very high(≥ 90)68%
Confident(70–90)8%
Low(50–70)5%
Very low(< 50)19%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Osteogenesis imperfecta

Disease associations (Open Targets)

autosomal recessive omodysplasia
0.74
omodysplasia
0.64
COVID-19
0.54
dengue disease
0.46
smoking initiation
0.41
insomnia
0.40
refractive error
0.40
Abnormality of the skeletal system
0.37
alcohol drinking
0.37
primary angle-closure glaucoma
0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Glypican-6

Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling