GPNMB

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Pigmentary skin disorders

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• familial primary localized cutaneous amyloidosis

  0.70

• Parkinson disease

  0.50

• amyloidosis cutis dyschromia

  0.46

• primary cutaneous amyloidosis

  0.37

• lymphoma

  0.37

• endometriosis

  0.36

• temporomandibular joint disorder

  0.31

• type 2 diabetes mellitus

  0.27

• response to antihypertensive drug

  0.23

• hereditary disease

  0.20

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)