GPR156

Chr 3q13.33

G protein-coupled receptor 156

Aliases:: PGR28, GABABL
MANE:: ENST00000464295.6

OMIM: 610464 ↗NCBI: 165829 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

GPR156 · Q8NFN8

v62025-08-01

Predicted Aligned Error matrix for GPR156 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

55.5/ 100

Low

814 residues

Confidence breakdown

Very high(≥ 90)12%
Confident(70–90)21%
Low(50–70)12%
Very low(< 50)55%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hearing loss, autosomal recessive 121
0.47
Sensorineural hearing impairment
0.37
sensorineural hearing loss disorder
0.37
deafness
0.32
hearing loss, autosomal recessive
0.32
Graves disease
0.25
developmental and/or epileptic encephalopathy with spike-wave activation in sleep
0.09
Rolandic epilepsy
0.09
Lennox-Gastaut syndrome
0.08
Landau-Kleffner syndrome
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Probable G protein-coupled receptor 156

Orphan G protein-coupled receptor involved in the regulation of hair cell orientation in mechanosensory organs of the inner ear. It is required to trigger a 180 degree reversal in hair cell orientation, creating a virtual line of polarity reversal (LPR) across which stereociliary bundles are arranged in opposite orientations