G protein-coupled receptor 179
Annotations refreshed 9 hours ago.
Diagnostic Grade (Green)
Retinal disorders
BIALLELIC, autosomal or pseudoautosomalGlaucoma (developmental)
Intellectual disability
BIALLELIC, autosomal or pseudoautosomalStructural eye disease
BIALLELIC, autosomal or pseudoautosomalcongenital stationary night blindness
Retinal dystrophy
optic atrophy
skin disorder
hereditary disease
retinitis pigmentosa
myopia
open-angle glaucoma
Leber congenital amaurosis
Cone rod dystrophy
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Probable G protein-coupled receptor 179
Orphan receptor involved in vision (PubMed:22325362, PubMed:24084093). Required for signal transduction through retinal depolarizing bipolar cells (PubMed:22325362). Acts as an atypical G protein-coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1 (By similarity)
Curated MONDO disease pages that list GPR179 among their top associated genes.
GPR179 · Q6PRD1
Mean pLDDT
42.8/ 100
Very low
2,367 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
