GPSM2

Chr 1p13.3

G protein signaling modulator 2

Aliases:: LGN, Pins
MANE:: ENST00000264126.9

OMIM: 609245 ↗NCBI: 29899 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

GPSM2 · P81274

v62025-08-01

Predicted Aligned Error matrix for GPSM2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

66.9/ 100

Low

684 residues

Confidence breakdown

Very high(≥ 90)45%
Confident(70–90)5%
Low(50–70)9%
Very low(< 50)41%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Hydrocephalus
BIALLELIC, autosomal or pseudoautosomal
Malformations of cortical development
BIALLELIC, autosomal or pseudoautosomal
Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Chudley-McCullough syndrome
0.79
hearing loss, autosomal recessive
0.58
Rare genetic deafness
0.49
deafness
0.49
hereditary disease
0.41
neurodegenerative disease
0.37
breast-ovarian cancer, familial, susceptibility to, 2
0.34
gastric ulcer
0.18
hemorrhage
0.18
Hearing impairment
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

G protein-signaling modulator 2

Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Also plays an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity)