AlphaFold predicted structure
GPT2 · Q8TD30
Mean pLDDT
91.6/ 100
Very high
523 residues
Confidence breakdown
- Very high(≥ 90)89%
- Confident(70–90)3%
- Low(50–70)1%
- Very low(< 50)8%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
GPT2
Chr 16q11.2glutamic--pyruvic transaminase 2
- Aliases:
- ALT2
- MANE:
- ENST00000340124.9
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Childhood onset hereditary spastic paraplegia
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalSevere microcephaly
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
glutamate pyruvate transaminase 2 deficiency
0.76neurodegenerative disease
0.46hereditary disease
0.45Intellectual disability
0.27hereditary spastic paraplegia 73
0.27lupus erythematosus
0.26Rare genetic intellectual disability
0.26neurodevelopmental disorder
0.11Mild intellectual disability
0.11Delayed speech and language development
0.11
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Alanine aminotransferase 2
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate