AlphaFold predicted structure
GRIN2D · O15399
Mean pLDDT
63.2/ 100
Low
1,336 residues
Confidence breakdown
- Very high(≥ 90)15%
- Confident(70–90)37%
- Low(50–70)9%
- Very low(< 50)40%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
GRIN2D
Chr 19q13.33glutamate ionotropic receptor NMDA type subunit 2D
- Aliases:
- GluN2D, EB11, NR2D
- MANE:
- ENST00000263269.4
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownEarly onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
developmental and epileptic encephalopathy, 46
0.74Alzheimer disease
0.62Parkinson disease
0.61influenza
0.60infection
0.59depressive disorder
0.59major depressive disorder
0.59alcohol dependence
0.58dementia
0.57cerebral atherosclerosis
0.56
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Glutamate receptor ionotropic, NMDA 2D
Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:27616483, PubMed:28126851, PubMed:9489750). Participates in synaptic plasticity for learning and memory formation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626, PubMed:27616483, PubMed:28126851, PubMed:9489750). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:9489750)
Diseases associated with GRIN2D
Curated MONDO disease pages that list GRIN2D among their top associated genes.