GRK1

Chr 13q34

G protein-coupled receptor kinase 1

Aliases:: GPRK1, RK
MANE:: ENST00000335678.7

OMIM: 180381 ↗NCBI: 6011 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

GRK1 · Q15835

v62025-08-01

Predicted Aligned Error matrix for GRK1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

91.3/ 100

Very high

563 residues

Confidence breakdown

Very high(≥ 90)79%
Confident(70–90)15%
Low(50–70)3%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Retinal disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Oguchi disease-2
0.66
Oguchi disease
0.53
Retinal dystrophy
0.50
congenital stationary night blindness
0.28
autoimmune disorder of central nervous system
0.22
hereditary disease
0.19
epilepsy
0.16
pancreas disorder
0.14
metabolic disease
0.14
alopecia areata
0.14

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Rhodopsin kinase GRK1

Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity)