AlphaFold predicted structure
GRM6 · O15303
Mean pLDDT
85.6/ 100
Confident
877 residues
Confidence breakdown
- Very high(≥ 90)56%
- Confident(70–90)33%
- Low(50–70)4%
- Very low(< 50)7%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
GRM6
Chr 5q35.3glutamate metabotropic receptor 6
- Aliases:
- GPRC1F, mGlu6, MGLUR6, CSNB1B
- MANE:
- ENST00000517717.3
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
BIALLELIC, autosomal or pseudoautosomalRetinal disorders
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalGlaucoma (developmental)
Intellectual disability
BIALLELIC, autosomal or pseudoautosomalStructural eye disease
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
congenital stationary night blindness
0.69Retinal dystrophy
0.51Leber congenital amaurosis
0.36hereditary disease
0.19major depressive disorder
0.12information processing speed
0.12optic atrophy
0.11myopia
0.11retinitis pigmentosa
0.10Cone rod dystrophy
0.10
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Metabotropic glutamate receptor 6
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision
Diseases associated with GRM6
Curated MONDO disease pages that list GRM6 among their top associated genes.