GRM7

Chr 3p26.1

glutamate metabotropic receptor 7

Aliases:: GLUR7, GPRC1G, mGlu7, MGLUR7, PPP1R87
MANE:: ENST00000357716.9

OMIM: 604101 ↗NCBI: 2917 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

GRM7 · Q14831

v62025-08-01

Predicted Aligned Error matrix for GRM7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.4/ 100

Confident

915 residues

Confidence breakdown

Very high(≥ 90)55%
Confident(70–90)31%
Low(50–70)8%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities
0.79
Global developmental delay
0.46
neurodevelopmental disorder
0.37
early-infantile DEE
0.37
autosomal recessive non-syndromic intellectual disability
0.37
Brain atrophy
0.35
Seizure
0.35
Hypotonia
0.35
microcephaly
0.34
Bilateral multifocal epileptiform discharges
0.34

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Metabotropic glutamate receptor 7

G protein-coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (PubMed:9473604)