GSTZ1

Chr 14q24.3

glutathione S-transferase zeta 1

Aliases:: GSTZ1-1, MAAI, MAI
MANE:: ENST00000216465.10

OMIM: 603758 ↗NCBI: 2954 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

GSTZ1 · O43708

v62025-08-01

Predicted Aligned Error matrix for GSTZ1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

97.3/ 100

Very high

216 residues

Confidence breakdown

Very high(≥ 90)96%
Confident(70–90)2%
Low(50–70)1%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

maleylacetoacetate isomerase deficiency
0.65
exostosis
0.26
placental abruption
0.24
hepatocellular carcinoma
0.12
familial idiopathic steroid-resistant nephrotic syndrome
0.07
nephronophthisis
0.07
focal segmental glomerulosclerosis
0.07
neoplasm
0.07
retinitis pigmentosa
0.07
Hepatic fibrosis
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Maleylacetoacetate isomerase

Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Also has low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid