GTF3C3

Chr 2q33.1

general transcription factor IIIC subunit 3

Aliases:: TFiiiC2-102, TFIIIC102
MANE:: ENST00000263956.8

OMIM: 604888 ↗NCBI: 9330 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

GTF3C3 · Q9Y5Q9

v62025-08-01

Predicted Aligned Error matrix for GTF3C3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.3/ 100

Confident

886 residues

Confidence breakdown

Very high(≥ 90)41%
Confident(70–90)40%
Low(50–70)6%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures
0.69
neurodegenerative disease
0.45
complex neurodevelopmental disorder
0.42
chromosome 2q32-q33 deletion syndrome
0.30
neurodevelopmental disorder
0.12
alcohol drinking
0.12
stroke disorder
0.11
spinal cord injury
0.10
adrenal gland hyperfunction
0.04
hyperaldosteronism
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

General transcription factor 3C polypeptide 3

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters