GTF3C5

Chr 9q34.13

general transcription factor IIIC subunit 5

Aliases:: TFiiiC2-63, TFIIIC63, TFIIICepsilon
MANE:: ENST00000372097.10

OMIM: 604890 ↗NCBI: 9328 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

GTF3C5 · Q9Y5Q8

v62025-08-01

Predicted Aligned Error matrix for GTF3C5 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.4/ 100

Confident

519 residues

Confidence breakdown

Very high(≥ 90)47%
Confident(70–90)24%
Low(50–70)13%
Very low(< 50)17%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.50
complex neurodevelopmental disorder
0.42
Intellectual disability
0.37
neurodevelopmental disorder
0.37
thrombocytopenia 4
0.28
hemorrhagic disease
0.28
disorder of visual system
0.21
neuroendocrine neoplasm
0.20
myeloproliferative disorder
0.14
myopathy, myofibrillar, 12, infantile-onset, with cardiomyopathy
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

General transcription factor 3C polypeptide 5

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters