HAVCR1

Hepatitis A virus cellular receptor 1

Phosphatidylserine receptor that plays an important functional role in regulatory B-cell homeostasis including generation, expansion and suppressor functions (PubMed:18082433, PubMed:18414680). Involved in efferocytosis, the process by which apoptotic cells are removed, by binding to phosphatidylserine present on apoptotic cells and promoting their engulfment (PubMed:18082433). Confers phagocytic ability on injured kidney epithelial cells, allowing them to bind to and internalize apoptotic bodies and necrotic debris following kidney injury (PubMed:17471468, PubMed:18414680). The ectodomain binds to the surface of apoptotic kidney epithelial cells via phosphatidylserine and oxidized phospholipids exposed on the cell membrane of the apoptotic cells (PubMed:18414680). HAVCR1-expressing cells are also capable of phagocytosing Gram-negative and Gram-positive bacteria (PubMed:18414680). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Acts as a regulator of T-cell proliferation (By similarity). Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity)