HCN2

Chr 19p13.3

hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

Aliases:: BCNG-2, HAC-1
MANE:: ENST00000251287.3

OMIM: 602781 ↗NCBI: 610 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

HCN2 · Q9UL51

v62025-08-01

Predicted Aligned Error matrix for HCN2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

70.1/ 100

Confident

889 residues

Confidence breakdown

Very high(≥ 90)35%
Confident(70–90)24%
Low(50–70)7%
Very low(< 50)34%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Early onset or syndromic epilepsy
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Childhood onset dystonia, chorea or related movement disorder
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Intellectual disability
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

febrile seizures, familial, 2
0.64
neurodegenerative disease
0.50
complex neurodevelopmental disorder
0.46
neurodevelopmental disorder
0.44
Alzheimer disease
0.34
Parkinson disease
0.34
multiple sclerosis
0.32
lysosomal storage disease
0.32
Neurodevelopmental delay
0.27
smoking initiation
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity)