AlphaFold predicted structure
HCN4 · Q9Y3Q4
Mean pLDDT
59.6/ 100
Low
1,203 residues
Confidence breakdown
- Very high(≥ 90)25%
- Confident(70–90)19%
- Low(50–70)3%
- Very low(< 50)53%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
HCN4
Chr 15q24.1hyperpolarization activated cyclic nucleotide gated potassium channel 4
- MANE:
- ENST00000261917.4
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Progressive cardiac conduction disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedPaediatric or syndromic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownBrugada syndrome and cardiac sodium channel disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedShort QT syndrome
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
sick sinus syndrome 2, autosomal dominant
0.73atrial fibrillation
0.70heart failure
0.60Brugada syndrome 8
0.59angina pectoris
0.58cardiac arrhythmia
0.55Abnormality of the cardiovascular system
0.51atrial flutter
0.50familial sick sinus syndrome
0.47Left ventricular noncompaction cardiomyopathy
0.44
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Hyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation (PubMed:10228147, PubMed:10430953, PubMed:20829353). Exhibits higher selectivity for K(+) over Na(+) ions (PubMed:10228147). Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat (Probable) (PubMed:10228147, PubMed:16407510, PubMed:19165230). Contributes to the native pacemaker currents in neurons (Ih) (Probable). May mediate responses to sour stimuli (By similarity)
Diseases associated with HCN4
Curated MONDO disease pages that list HCN4 among their top associated genes.