AlphaFold predicted structure
HFM1 · A2PYH4
Mean pLDDT
65.4/ 100
Low
1,435 residues
Confidence breakdown
- Very high(≥ 90)33%
- Confident(70–90)24%
- Low(50–70)5%
- Very low(< 50)38%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
HFM1
Chr 1p22.2helicase for meiosis 1
- Aliases:
- MER3, FLJ39011, FLJ36760
- MANE:
- ENST00000370425.8
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Primary ovarian insufficiency
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
primary ovarian failure
0.55genetic non-acquired premature ovarian failure
0.40neurodegenerative disease
0.40Azoospermia
0.34diabetes mellitus
0.28obesity disorder
0.26bone Paget disease
0.26stomach disorder
0.26limb injury
0.25liver disorder
0.25
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Probable ATP-dependent DNA helicase HFM1
Required for crossover formation and complete synapsis of homologous chromosomes during meiosis