HIVEP2

Chr 6q24.2

HIVEP zinc finger 2

Aliases:: MBP-2, HIV-EP2, MIBP1, ZAS2, Schnurri-2
MANE:: ENST00000367603.8

OMIM: 143054 ↗NCBI: 3097 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

HIVEP2 · P31629

v62025-08-01

Predicted Aligned Error matrix for HIVEP2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

36.3/ 100

Very low

2,446 residues

Confidence breakdown

Very high(≥ 90)3%
Confident(70–90)3%
Low(50–70)2%
Very low(< 50)93%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

intellectual disability, autosomal dominant 43
0.74
Intellectual disability
0.54
hereditary disease
0.53
diabetes mellitus
0.48
type 2 diabetes mellitus
0.47
Angelman syndrome
0.43
hypertensive disorder
0.38
hypothyroidism
0.38
autosomal dominant non-syndromic intellectual disability
0.37
inflammation of heart layer
0.34

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transcription factor HIVEP2

This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation