AlphaFold predicted structure
HMOX1 · P09601
Mean pLDDT
82.9/ 100
Confident
288 residues
Confidence breakdown
- Very high(≥ 90)73%
- Confident(70–90)2%
- Low(50–70)6%
- Very low(< 50)20%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
HMOX1
Chr 22q12.3heme oxygenase 1
- Aliases:
- bK286B10, HO-1
- MANE:
- ENST00000216117.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
heme oxygenase 1 deficiency
0.69amyloidosis
0.47neurodegenerative disease
0.46cystic fibrosis
0.39chronic obstructive pulmonary disease
0.36digestive system disorder
0.28neoplasm
0.12acute kidney injury
0.12Alzheimer disease
0.12hepatocellular carcinoma
0.12
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Heme oxygenase 1
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, PubMed:19556236, PubMed:7703255). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707)
Diseases associated with HMOX1
Curated MONDO disease pages that list HMOX1 among their top associated genes.