HOMER2

Chr 15q25.2

homer scaffold protein 2

Aliases:: CPD, Cupidin, Vesl-2, HOMER-2B, HOMER-2
MANE:: ENST00000450735.7

OMIM: 604799 ↗NCBI: 9455 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

HOMER2 · Q9NSB8

v62025-08-01

Predicted Aligned Error matrix for HOMER2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

88.4/ 100

Confident

354 residues

Confidence breakdown

Very high(≥ 90)78%
Confident(70–90)9%
Low(50–70)4%
Very low(< 50)10%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Monogenic hearing loss
MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed)

Disease associations (Open Targets)

autosomal dominant nonsyndromic hearing loss
0.60
deafness
0.54
sarcoidosis
0.24
ovarian dysfunction
0.22
preeclampsia
0.22
Non-syndromic genetic deafness
0.20
hereditary disease
0.19
nonsyndromic genetic hearing loss
0.18
biliary tract disorder
0.16
bipolar disorder
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Homer protein homolog 2

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901)