HOXA11

Chr 7p15.2

homeobox A11

MANE:: ENST00000006015.4

OMIM: 142958 ↗NCBI: 3207 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

HOXA11 · P31270

v62025-08-01

Predicted Aligned Error matrix for HOXA11 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

59.8/ 100

Low

313 residues

Confidence breakdown

Very high(≥ 90)18%
Confident(70–90)7%
Low(50–70)30%
Very low(< 50)44%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Inherited bleeding disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Bleeding and platelet disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Cytopenias and congenital anaemias
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Cytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Limb disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Skeletal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Radio-ulnar synostosis - amegakaryocytic thrombocytopenia
0.60
radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome
0.39
endometrial endometrioid adenocarcinoma
0.37
colorectal adenocarcinoma
0.37
neurodegenerative disease
0.35
Abnormality of the skeletal system
0.32
non-small cell lung carcinoma
0.31
hepatocellular carcinoma
0.31
breast carcinoma
0.30
glioma
0.30

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Homeobox protein Hox-A11

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis