AlphaFold predicted structure
HRAS · P01112
Mean pLDDT
91.9/ 100
Very high
189 residues
Confidence breakdown
- Very high(≥ 90)78%
- Confident(70–90)14%
- Low(50–70)3%
- Very low(< 50)5%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
HRAS
Chr 11p15.5HRas proto-oncogene, GTPase
- MANE:
- ENST00000311189.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Adult solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownChildhood solid tumours
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownChildhood solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownDDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownEarly onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownEmbryonal tumour of possible germline origin
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFamilial rhabdomyosarcoma
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
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Disease associations (Open Targets)
Costello syndrome
0.88linear nevus sebaceous syndrome
0.76Linear nevus sebaceus syndrome
0.75urinary bladder cancer
0.72nevus, epidermal
0.72urinary bladder carcinoma
0.69Noonan syndrome
0.68thyroid cancer, nonmedullary, 2
0.66cancer
0.65large congenital melanocytic nevus
0.62
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
GTPase HRas
Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:40934300)
Diseases associated with HRAS
Curated MONDO disease pages that list HRAS among their top associated genes.