HYDIN

Chr 16q22.2

HYDIN axonemal central pair apparatus protein

Aliases:: DKFZp434D0513, KIAA1864, PPP1R31, CILD5
MANE:: ENST00000393567.7

OMIM: 610812 ↗NCBI: 54768 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

HYDIN · Q4G0P3-2isoform

No predicted structure exists for the canonical Q4G0P3 sequence; metrics below describe this isoform.

v62025-08-01

Predicted Aligned Error matrix for HYDIN — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.2/ 100

Confident

1,098 residues

Confidence breakdown

Very high(≥ 90)29%
Confident(70–90)54%
Low(50–70)10%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Primary ciliary disorders
BIALLELIC, autosomal or pseudoautosomal
Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal
COVID-19 research
Ductal plate malformation
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Laterality disorders and isomerism

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Disease associations (Open Targets)

primary ciliary dyskinesia 5
0.77
primary ciliary dyskinesia
0.69
Abnormal sperm morphology
0.34
Reduced sperm motility
0.34
hypertensive disorder
0.31
ovarian neoplasm
0.31
scoliosis
0.29
Hepatitis
0.28
color vision disorder
0.27
glomerulonephritis
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Axonemal central pair apparatus protein HYDIN

Required for ciliary motility (By similarity). Required for localization of SPEF2 to the ciliary axoneme in ciliated respiratory epithelial cells (PubMed:31545650)