HYOU1

Chr 11q23.3

hypoxia up-regulated 1

Aliases:: ORP150, HSP12A, Grp170
MANE:: ENST00000617285.5

OMIM: 601746 ↗NCBI: 10525 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

HYOU1 · Q9Y4L1

v62025-08-01

Predicted Aligned Error matrix for HYOU1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.3/ 100

Confident

999 residues

Confidence breakdown

Very high(≥ 90)67%
Confident(70–90)9%
Low(50–70)3%
Very low(< 50)20%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.54
granulocytopenia with immunoglobulin abnormality
0.52
dengue disease
0.37
coronary artery disorder
0.24
type 2 diabetes mellitus
0.12
infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome
0.12
gallstones
0.12
neoplasm
0.10
obesity disorder
0.09
bilateral striopallidodentate calcinosis
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Hypoxia up-regulated protein 1

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding