ICOSLG

Chr 21q22.3

inducible T cell costimulator ligand

Aliases:: KIAA0653, GL50, B7-H2, B7RP-1, B7H2
MANE:: ENST00000407780.8

OMIM: 605717 ↗NCBI: 23308 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ICOSLG · O75144

v62025-08-01

Predicted Aligned Error matrix for ICOSLG — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.6/ 100

Confident

302 residues

Confidence breakdown

Very high(≥ 90)62%
Confident(70–90)15%
Low(50–70)7%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

immunodeficiency 119
0.35
combined immunodeficiency
0.31
rheumatoid arthritis
0.28
Combined T and B cell immunodeficiency
0.27
hereditary disease
0.27
depressive disorder
0.19
severe combined immunodeficiency
0.18
cardiomyopathy
0.15
benign urinary system neoplasm
0.15
neoplasm
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

ICOS ligand

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed:11007762, PubMed:11023515, PubMed:30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed:30498080)